oral bioavailability — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T2086	ELN-441958	ELN 441958	Bradykinin Receptor
	ELN-441958 is a potent, neutral antagonist of B1 receptor, inhibits the binding of the B1 agonist ligand [3H]DAKD to IMR-90 cells with Ki of 0.26 nM. ELN-441958(ELN 441958) is highly selective for B1 over B2 receptors.		Bradykinin Receptor
T1770	GNE-9605		LRRK2
	GNE-9605 is a highly effective, specifical, and brain-penetrant LRRK2 inhibitor (IC50: 19 nM).		LRRK2
T13099	TC ASK 10		ASK , MAPK
	TC ASK 10 is a potent, selective and orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1)(IC50 of 14 nM).		ASK , MAPK
T10606	BRD0705		GSK-3
	BRD0705 is a potent, paralog selective and orally active GSK3α inhibitor (IC50: 66 nM; Kd: 4.8 μM). BRD0705 displays increased selectivity for GSK3α (8-fold) versus GSK3β (IC50: 515 nM).		GSK-3
TQ0239	PF-06291874	Glucagon receptor antagonists-4	Glucagon Receptor
	PF-06291874 (Glucagon receptor antagonists-4) (Glucagon receptor antagonists-4) is a highly effective and orally active antagonist of the glucagon receptor.		Glucagon Receptor
T24493	Monoelaidin
	Monoelaidin is a poorly water-soluble drug enhancer of solubility and oral bioavailability.
T69757	PDDC inhibitor
	PDDC is the first nSMase2 inhibitor that possesses both favorable pharmacodynamics and pharmacokinetic (PK) parameters, including substantial oral bioavailability, brain penetration, and significant inhibition of exosome...
T9173	HM-30181 mesylate monohydrate		P-gp
	HM-30181 mesylate monohydrate is an oral P-glycoprotein (P-gp) inhibitor, used to enhance the oral bioavailability of P-gp substrate drugs.		P-gp
T7897	PK150		Others , Antibacterial
	PK150 shows oral bioavailability and antibacterial activity against several pathogenic strains at submicromolar concentrations.		Others , Antibacterial
T8850	Sbp-7455		Autophagy
	SBP-7455 potently inhibited ULK1/2 enzymatic activity in vitro and in cells, reduced the viability of TNBC cells and had oral bioavailability in mice.		Autophagy
T7614	Eniluracil	GW776C85,5-Ethynyluracil	Others
	Eniluracil (GW776C85) is an orally activedihydropyrimidine dehydrogenase (DPD) inhibitor,increases the oral bioavailability of 5-FU to 100%, facilitating uniform absorption and predictable toxicity.		Others
TQ0039	(±)-Zanubrutinib	(±)-BGB-3111	BTK
	(±)-Zanubrutinib ((±)-BGB-3111) is a potent and orally available Bruton's tyrosine kinase (Btk) inhibitor that demonstrates superior oral bioavailability, achieving higher exposure and more complete target inhibi.		BTK
T15409	GNF179		Parasite
	GNF179 is an optimized 8,8-dimethyl IP analog. It exhibited the potency(4.8 nM against the multidrug resistant strain W2) in vitro metabolic stability and in vivo oral bioavailability.		Parasite
T26863	BMS-929075	BMS 929075,BMS929075	HCV Protease
	BMS-929075 is an orally active HCV NS5B replicase (HCV NS5B replicase) palm site variant inhibitor with potency, high oral bioavailability and pharmacokinetic parameters.BMS-929075 shows cytotoxicity.		HCV Protease
T3312	AM-2394	AM2394	Glucokinase
	AM-2394 is an effective and specific Glucokinase agonist (GKA, EC50: 60 nM), which catalyzes the phosphorylation of glucose to glucose-6-phosphate. AM-2394(AM2394) increases the affinity of GK for glucose by approximatel...		Glucokinase
T9692	Paltusotine		Somatostatin
	Paltusotine is a nonpeptide, small molecule somatostatin type 2 (SST2) receptor agonist with high oral bioavailability. Paltusotine maintains GH and IGF-1 levels in acromegaly patients		Somatostatin
T60538	SARS-CoV-2-IN-14	3',5-Dichlorosalicylanilide	SARS-CoV
	SARS-CoV-2-IN-14 is a potent and oral inhibitor of SARS-CoV-2 (IC50:0.39 μM), which is an analogue of niclosamide. SARS-CoV-2-IN-14 was more stable than niclosamide in the determination of human plasma and liver S9 enzym...		SARS-CoV
TN1918	Medicarpin		Apoptosis , BCL , ROS , JNK
	Medicarpin, a legume phytoalexin, acts as an estrogen receptor (ER) agonist, can stimulate osteoblast differentiation likely via ERα², promote achievement of peak bone mass, and is devoid of uterine estrogenicity; in add...		Apoptosis , BCL , ROS , JNK
T73447	NP10679
	NP10679 is a selective, pH dependent GluN2B subunit -specific N-methyl-D-aspartate ( NMDA ) receptor inhibitor with high oral bioavailability and good brain penetration. NP10679 inhibits GluN2B with IC 50 s of 23 and 142...
T26690	AVN-101		5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	AVN-101 is a potent 5-HT7 receptor antagonist.		5-HT Receptor , Adrenergic Receptor , Histamine Receptor